tecovirimat will boost the amount or influence of modafinil by affecting hepatic enzyme CYP2C19 metabolism. Use Warning/Keep track of. Tecovirimat can be a weak inhibitor of CYP2C8 and CYP2C19. Observe for adverse outcomes if coadministered with delicate substrates of these enzymes.
nelfinavir will raise the degree or outcome of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
Stay away from or substitute One more drug for these remedies when probable. Assess for lack of therapeutic effect if medication needs to be coadministered. Modify dose In keeping with prescribing information and facts if needed.
With that intellect, what do we at this time know about modafinil’s opportunity for making physiological tolerance and drug-dependence?
Get this medication simultaneously on a daily basis. Never change the time of day you're taking modafinil devoid of speaking first with the doctor.
itraconazole will increase the stage or influence of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.
modafinil will boost the amount or outcome of clobazam by affecting hepatic enzyme CYP2C19 metabolism. Use Warning/Watch. Dosage adjustment might be required; CYP2C19 inhibitors may possibly bring about increased publicity to N-desmethylclobazam (Energetic metabolite).
Doses as much as four hundred mg/day, given as a single dose, are very well tolerated, but there is no regular proof this dose confers further benefit over and above that of your two hundred mg/working day dose
No sizeable improvements in body bodyweight have been noticed in scientific trials, While reduced appetite and weight-loss happen to be famous in youngsters and adolescents.
Modafinil can also be accessible to astronauts aboard the International Space Station for that management of exhaustion due to circadian dyssynchrony in orbit.[seventy nine]
Modafinil is utilized to help Individuals who have narcolepsy, obstructive slumber apnea/hypopnea syndrome (OSAHS), or shift operate rest condition (SWSD) to stay awake throughout the day. Modafinil doesn't cure these circumstances and will only function as long as you carry on to consider it.
Keep away from or Use more info Alternate Drug. Steer clear of coadministration of delicate CYP3A4 substrates with ivosidenib or switch with alternative therapies. If coadministration is unavoidable, keep track of people for lack of therapeutic impact of such medications.
modafinil will increase the stage or impact of pantoprazole by influencing hepatic enzyme CYP2C19 metabolism. Minimal/Significance Mysterious. Net effect on pantoprazole steps unknown due to opposing results of CYP450 enzymes; watch
To maintain from obtaining Expecting, use One more form of start Manage while you are making use of this medicine and for a single thirty day period after your previous dose. Other sorts of beginning Handle incorporate condoms, diaphragms, or contraceptive foams or jellies.